General Information

  • ID:  hor002790
  • Uniprot ID:  P58706
  • Protein name:  Antho-RIamide-2
  • Gene name:  NA
  • Organism:  Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
  • Family:  NA
  • Source:  Animal
  • Expression:  Neuron specific.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Anthopleura (genus), Actiniidae (family), Actiniaria (order), Hexacorallia (subclass), Anthozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YRI
  • Length:  3(2-4)
  • Propeptide:  FYRI
  • Signal peptide:  NA
  • Modification:  T3 Isoleucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibits spontaneous contractions in several muscle groups. May be involved in the expansion phase of feeding behavior in sea anemones.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9UHF0-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q9UHF0-F1.pdbhor002790_AF2.pdbhor002790_ESM.pdb

Physical Information

Mass: 48639 Formula: C21H34N6O5
Absent amino acids: ACDEFGHKLMNPQSTVW Common amino acids: IRY
pI: 9.35 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 1
Hydrophobicity: -43.33 Boman Index: -1014
Half-Life / Aliphatic Index: 2.8 hour Aliphatic Index: 130
Instability Index: -4970 Extinction Coefficient cystines: 1490
Absorbance 280nm: 745

Literature

  • PubMed ID:  1821096
  • Title:  Isolation of two novel neuropeptides from sea anemones: the unusual, biologically active L-3-phenyllactyl-Tyr-Arg-Ile-NH2 and its des-phenyllactyl fragment Tyr-Arg-Ile-NH2.