General Information

  • ID:  hor002789
  • Uniprot ID:  P58706
  • Protein name:  Antho-RIamide-1
  • Gene name:  NA
  • Organism:  Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
  • Family:  NA
  • Source:  Animal
  • Expression:  Neuron specific.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Anthopleura (genus), Actiniidae (family), Actiniaria (order), Hexacorallia (subclass), Anthozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  FYRI
  • Length:  4(1-4)
  • Propeptide:  FYRI
  • Signal peptide:  NA
  • Modification:  T1 3-phenyllactic acid;T4 Isoleucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibits spontaneous contractions in several muscle groups. May be involved in the expansion phase of feeding behavior in sea anemones.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P20366-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P20366-F1.pdbhor002789_AF2.pdbhor002789_ESM.pdb

Physical Information

Mass: 65140 Formula: C30H43N7O6
Absent amino acids: ACDEGHKLMNPQSTVW Common amino acids: FIRY
pI: 9.35 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: 37.5 Boman Index: -716
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 97.5
Instability Index: 4672.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 496.67

Literature

  • PubMed ID:  1821096
  • Title:  Isolation of two novel neuropeptides from sea anemones: the unusual, biologically active L-3-phenyllactyl-Tyr-Arg-Ile-NH2 and its des-phenyllactyl fragment Tyr-Arg-Ile-NH2.