HORDB

ID: hor002606
Uniprot ID: Q11088
Protein name: NLP-1
Gene name: nlp-1
Organism: Caenorhabditis elegans
Family: NA
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0001966 thigmotaxis; GO:0071244 cellular response to carbon dioxide; GO:1903745 negative regulation of nematode pharyngeal pumping
GO CC: NA

Sequence: MDANAFRMSF
Length: 10(26-35)
Propeptide: MKATFVLACLLVIAAVSHADLLPKRMDANAFRMSFGKRSVSNPAEAKRMDPNAFRMSFGKRSAEQNEQANKEDKATSDKLYDDTKFEEMKRMDANAFRMSFGKRSDAHQAADDQVEYVNDDFSLPEQKRMDANAFRMSFGKRVNLDPNSFRMSFGKRSTVGYNLDARNYFVGLGRR
Signal peptide: MKATFVLACLLVIAAVSHA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: In AWC olfactory sensory neurons, required for the detection of preferred food sources.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002606_AF2.pdb

hor002606_ESM.pdb

Mass:	135008	Formula:	C51H76N14O15S2
Absent amino acids:	CEGHIKLPQTVWY	Common amino acids:	AFM
pI:	6.34	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	4
Hydrophobicity:	7	Boman Index:	-1940
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	20
Instability Index:	5294	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 20013198
Title: Approaches to Identify Endogenous Peptides in the Soil Nematode Caenorhabditis elegans