General Information

  • ID:  hor002505
  • Uniprot ID:  NA
  • Protein name:  5-HT moduline
  • Gene name:  NA
  • Organism:  NA
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  LSAL
  • Length:  4
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Act as a specific endogenous antagonist to central 5-HT1B/1D?receptors;
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002505_AF2.pdbhor002505_ESM.pdb

Physical Information

Mass: 45619 Formula: C18H34N4O6
Absent amino acids: CDEFGHIKMNPQRTVWY Common amino acids: L
pI: 6.11 Basic residues: 0
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: 215 Boman Index: 825
Half-Life: 5.5 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 220
Instability Index: 750 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  12642380
  • Title:  5-HT Moduline: An Endogenous Inhibitor of 5-HT(1B/1D)-mediated Contraction in Pulmonary Arteries