General Information

  • ID:  hor002494
  • Uniprot ID:  P0DTV3
  • Protein name:  lesueurin
  • Gene name:  NA
  • Organism:  Ranoidea lesueuri (Lesueur's frog) (Litoria lesueurii)
  • Family:  Frog skin active peptide (FSAP) family
  • Source:  animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Litoria (genus), Pelodryadinae (subfamily), Hylidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005516 calmodulin binding
  • GO BP:  GO:0006952 defense response
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GLLDILKKVGKVA
  • Length:  13
  • Propeptide:  GLLDILKKVGKVA
  • Signal peptide:  NA
  • Modification:  T13 Alanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibit the formation of the ubiquitous chemical messenger nitric oxide from neuronal nitric oxide synthase (nNOS)
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: 16.2*10(-6)m
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002494_AF2.pdbhor002494_ESM.pdb

Physical Information

Mass: 156796 Formula: C63H116N16O16
Absent amino acids: CEFHMNPQRSTWY Common amino acids: KL
pI: 10.51 Basic residues: 3
Polar residues: 2 Hydrophobic residues: 7
Hydrophobicity: 77.69 Boman Index: 608
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 172.31
Instability Index: -860.77 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  11784303
  • Title:  Amphibian Peptides That Inhibit Neuronal Nitric Oxide Synthase. Isolation of Lesuerin From the Skin Secretion of the Australian Stony Creek Frog Litoria Lesueuri