General Information

  • ID:  hor002442
  • Uniprot ID:  B3EWL9
  • Protein name:  Myosuppressin
  • Gene name:  NA
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  Myosuppressin family
  • Source:  Animal
  • Expression:  Detected in larvae and adults. |In larvae, both myosuppressin and myosuppressin(2-10) are expressed in the CNS but not the midgut, thoracic perisympathetic organs (tPSO) and abdominal perisympathetic organs (aPSO). Myosuppressin is expressed in the ring g
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  TDVDHVFLRF
  • Length:  10(1-10)
  • Propeptide:  TDVDHVFLRF
  • Signal peptide:  NA
  • Modification:  T10 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibit spontaneous contraction of muscles
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002442_AF2.pdbhor002442_ESM.pdb

Physical Information

Mass: 140912 Formula: C58H85N15O16
Absent amino acids: ACEGIKMNPQSWY Common amino acids: DFV
pI: 5.41 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 5
Hydrophobicity: 24 Boman Index: -2063
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 97
Instability Index: 1323 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  20869420
  • Title:  Neuropeptides associated with the central nervous system of the cabbage root fly, Delia radicum (L).
  • PubMed ID:  22848525
  • Title:   Peptidomics of the agriculturally damaging larval stage of the cabbage root fly Delia radicum (Diptera: Anthomyiidae).