HORDB

ID: hor002378
Uniprot ID: P19863
Protein name: Motilin
Gene name: MLN
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Family: Motilin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Canis lupus (species), Canis (genus), Canidae (family), Caniformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
Mechanism: NA
Cross BBB: NO
Target: MLNR
Target Unid: B2NIZ6
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P19863-F1.pdb

hor002378_AF2.pdb

hor002378_ESM.pdb

Mass:	305982	Formula:	C120H194N36O34
Absent amino acids:	ACDMWY	Common amino acids:	EK
pI:	10.49	Basic residues:	6
Polar residues:	4	Hydrophobic residues:	6
Hydrophobicity:	-117.27	Boman Index:	-6957
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	66.36
Instability Index:	5052.73	Extinction Coefficient cystines:	0
Absorbance 280nm:	0