HORDB

ID: hor002372
Uniprot ID: Q8WMJ7
Protein name: Neurexophilin-4
Gene name: NXPH4
Organism: Macaca mulatta (Rhesus macaque)
Family: Neurexophilin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Macaca (genus), Cercopithecinae (subfamily), Cercopithecidae (family), Cercopithecoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: GO:0005576 extracellular region

Sequence: NCHVEYEKTNRARKHRPCLYDPSQVCFTEHTQSQAAWLCAKPYKVICIFVSFLSFDYKLVQKVCPDYNFQSEHPYFG
Length: 77(1-77)
Propeptide: NCHVEYEKTNRARKHRPCLYDPSQVCFTEHTQSQAAWLCAKPYKVICIFVSFLSFDYKLVQKVCPDYNFQSEHPYFG
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q8WMJ7-F1.pdb

hor002372_AF2.pdb

hor002372_ESM.pdb

Mass:	1051122	Formula:	C416H611N109O114S6
Absent amino acids:	M	Common amino acids:	CFKVYPQS
pI:	8.12	Basic residues:	13
Polar residues:	24	Hydrophobic residues:	23
Hydrophobicity:	-48.05	Boman Index:	-13344
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	58.18
Instability Index:	3503.51	Extinction Coefficient cystines:	14815
Absorbance 280nm:	194.93