General Information

  • ID:  hor002340
  • Uniprot ID:  P11925
  • Protein name:  Califin-C small subunit
  • Gene name:  NA
  • Organism:  Aplysia californica (California sea hare)
  • Family:  Molluscan ELH family
  • Source:  Animal
  • Expression:  atrial gland
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DSDVSLFNGDLLPNGRCS
  • Length:  18(37-54)
  • Propeptide:  ISINQDLKAITDMLLTEQIQARRRCLAALRQRLLDLDSDVSLFNGDLLPNGRCS
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Excites LB and LC cells of the abdominal ganglion and cause egg-laying
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P11925-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002340_AF2.pdbhor002340_ESM.pdb

Physical Information

Mass: 221247 Formula: C79H125N23O30S
Absent amino acids: AEHIKMQTWY Common amino acids: DLS
pI: 3.83 Basic residues: 1
Polar residues: 8 Hydrophobic residues: 5
Hydrophobicity: -32.78 Boman Index: -3962
Half-Life / Aliphatic Index: 1.1 hour Aliphatic Index: 81.11
Instability Index: 1414.44 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  3753705
  • Title:  Isolation and primary structure of the califins, three biologically active egg-laying hormone-like peptides from the atrial gland of Aplysia californica