HORDB

ID: hor002316
Uniprot ID: P01362
Protein name: Acidic peptide(9-26)
Gene name: NA
Organism: Aplysia californica (California sea hare)
Family: Molluscan ELH family
Source: Animal
Expression: Bag cell neurons.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: SNKDEEQRELLKAISNLL
Length: 18(253-270)
Propeptide: MKRPNNRPTNTMSLILCLTLSSLCVSSQSASVHGKNFATNRAVKSSSPFVVLSPDDNVVSMSGENGYRSALREAFDKSSRDYDDNGEDVFSNEKRRLRFHKRRLRFDRRDQDEGNFRRFPTNAVSMSADENSPFDLSNEDGAVYQRDLRAPRLRFYSLRKRAAGGMEQSEGQNPETESHSRRKRSVLTPSLSSLGESLESGISKRISINQDLKAITDMLLTEQIRERQRYLADLRQRLLEKGKRSSGVSLLTSNK
Signal peptide: MKRPNNRPTNTMSLILCLTLSSLCVSSQ
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: ELH acts as a neurotransmitter locally, upon neurons of the abdominal ganglion and as a hormone by diffusing into the circulating hemolymph and modulating the activity of other organs. It specifically causes contraction of smooth muscle in the ovotestis a
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002316_AF2.pdb

hor002316_ESM.pdb

Mass:	240377	Formula:	C89H154N26O32
Absent amino acids:	CFGHMPTVWY	Common amino acids:	L
pI:	4.59	Basic residues:	3
Polar residues:	4	Hydrophobic residues:	6
Hydrophobicity:	-93.89	Boman Index:	-5438
Half-Life / Aliphatic Index:	1.9 hour	Aliphatic Index:	113.89
Instability Index:	4669.44	Extinction Coefficient cystines:	0
Absorbance 280nm:	0