General Information

  • ID:  hor002296
  • Uniprot ID:  A0A3P9JPF5
  • Protein name:  MCH gene-related peptide
  • Gene name:  NA
  • Organism:  Oryzias latipes (Japanese rice fish) (Japanese killifish)
  • Family:  Melanin-concentrating hormone family
  • Source:  Animal
  • Expression:  Brain
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oryzias (genus), Oryziinae (subfamily), Adrianichthyidae (family), Adrianichthyoidei (suborder), Beloniformes (order), Atherinomorphae (superorder), Ovalentaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0030354 melanin-concentrating hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
  • GO CC:  GO:0045202 synapse

Sequence Information

  • Sequence:  TADDNNQVLEHRNLAQQLNIPIL
  • Length:  23(95-117)
  • Propeptide:  MRRSVMSVIFATVLLFDCYAPSVASPMANTEDGSMEQDAFTSLLTNEATDNSLGEAEPIPVTKARVPRVIVIAADPSLWRDLRVLHGGMSVYRRTADDNNQVLEHRNLAQQLNIPILRRDTMRCMVGRVYRPCWEV
  • Signal peptide:  MRRSVMSVIFATVLLFDCYAPSVA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May be involved in modulating medaka behaviors
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A3P9JPF5-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002296_AF2.pdbhor002296_ESM.pdb

Physical Information

Mass: 302254 Formula: C112H185N35O38
Absent amino acids: CFGKMSWY Common amino acids: LN
pI: 4.37 Basic residues: 2
Polar residues: 5 Hydrophobic residues: 9
Hydrophobicity: -56.52 Boman Index: -5240
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 123.04
Instability Index: 3600.43 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  19118555
  • Title:  Mass Spectrometric Map of Neuropeptide Expression and Analysis of the Gamma-Prepro-Tachykinin Gene Expression in the Medaka (Oryzias Latipes) Brain