General Information

  • ID:  hor002290
  • Uniprot ID:  P91736
  • Protein name:  GLWamide
  • Gene name:  LOC100192300
  • Organism:  Hydra vulgaris (Hydra) (Hydra attenuata)
  • Family:  LWamide neuropeptide family
  • Source:  animal
  • Expression:  neurons
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Hydra (genus), Hydridae (family), Aplanulata (suborder), Anthoathecata (order), Hydroidolina (subclass), Hydrozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  KPNAYKGKLPIGLW
  • Length:  14
  • Propeptide:  MGMFERKKIVLLVSLICVSQQATNVQDANSKSTSTELKVVKPQKRVTPVKDAEKLSILRTQDNSLDLNTNGEEVWDELTHNIPLEYIEKIYNELNQLAQNENRPKRLWGATAAINTDNLNPEVENELENKKNAPVIEKFERPIGLWHKDIETKNPENRLPLGLWGKDSEPLPIGLWGKDADVNDDLKKEPLPIGLWGKDTDSTRGDNKPNAYKGKLPIGLWGKDNALTNDLGKKNNGKDSGPPPGLWGKDSKPIPGLWGKDNGPMTGLWGKKDVGPPPGLWGKKDQPPIGMWGRAGKRDSNPYPGLWGKKEEELENVDKEIEEDSLEEFPACLLENPPCEIQEKRYNIDKSGPPPGLWGKRSEKYQMNKPPWRGGMWGRSEILENSVHDSKKTNTIDMEHAEN
  • Signal peptide:  MGMFERKKIVLLVSLICVSQQ
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Be involved in regulating the excitability of specific muscles
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P91736-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002290_AF2.pdbhor002290_ESM.pdb

Physical Information

Mass: 181699 Formula: C77H121N19O17
Absent amino acids: CDEFHMQRSTV Common amino acids: K
pI: 10.64 Basic residues: 3
Polar residues: 4 Hydrophobic residues: 5
Hydrophobicity: -53.57 Boman Index: -265
Half-Life: 1.3 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 90.71
Instability Index: 1637.86 Extinction Coefficient cystines: 6990
Absorbance 280nm: 537.69

Literature

  • PubMed ID:  12798941
  • Title:  Identification of a New Member of the GLWamide Peptide Family: Physiological Activity and Cellular Localization in Cnidarian Polyps