HORDB

ID: hor002284
Uniprot ID: Q5PXH1
Protein name: Metastasis-suppressor KiSS-1
Gene name: KISS1
Organism: Macaca mulatta (Rhesus macaque)
Family: KISS1 family
Source: animal
Expression: In the hypothalamus, expression increases with puberty in both male and female monkeys. Robust expression in the region of the arcuate nucleus (ARC).
Disease: NA
Comments: NA
Taxonomy: Macaca (genus), Cercopithecinae (subfamily), Cercopithecidae (family), Cercopithecoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0031773 kisspeptin receptor binding
GO BP: GO:0007186 G protein-coupled receptor signaling pathway; GO:0007204 positive regulation of cytosolic calcium ion concentration
GO CC: GO:0005576 extracellular region

Sequence: SVENSRPTGQQLESLDLSAPWEQSLPCTERKPSATARLSRRGASLSSPAESSGSPQRRGLSAPSSRQIPAPQGAVLVQREKDLPNYNW
Length: 88
Propeptide: SVENSRPTGQQLESLDLSAPWEQSLPCTERKPSATARLSRRGASLSSPAESSGSPQRRGLSAPSSRQIPAPQGAVLVQREKDLPNYNW
Signal peptide: NA
Modification: T86 Phosphotyrosine
Glycosylation: NA
Mutagenesis: NA

Function: Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization.
Mechanism: NA
Cross BBB: NA
Target: KISS1R
Target Unid: F6YBI8
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q5PXH1-F1.pdb

hor002284_AF2.pdb

hor002284_ESM.pdb

Mass:	1106542	Formula:	C404H657N129O135S
Absent amino acids:	FHM	Common amino acids:	S
pI:	10.23	Basic residues:	11
Polar residues:	29	Hydrophobic residues:	23
Hydrophobicity:	-89.89	Boman Index:	-23819
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	63.3
Instability Index:	8564.32	Extinction Coefficient cystines:	12490
Absorbance 280nm:	143.56