HORDB

General Information

ID: hor002277
Uniprot ID: NA
Protein name: Kisspeptin
Gene name: NA
Organism: NA
Family: KISS1 family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: YNWNSFGLRY
Length: 10
Propeptide: NA
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Be an important regulator of reproductive behavior and gonadotrophin secretion
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002277_AF2.pdb

hor002277_ESM.pdb

Physical Information

Mass:	148014	Formula:	C63H82N16O16
Absent amino acids:	ACDEHIKMPQTV	Common amino acids:	NY
pI:	9.17	Basic residues:	1
Polar residues:	6	Hydrophobic residues:	3
Hydrophobicity:	-96	Boman Index:	-2071
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	39
Instability Index:	2179	Extinction Coefficient cystines:	8480
Absorbance 280nm:	942.22

Literature

PubMed ID: 20301214
Title: beta-Sheet Aggregation of kisspeptin-10 Is Stimulated by Heparin but Inhibited by Amphiphiles