General Information

  • ID:  hor002276
  • Uniprot ID:  NA
  • Protein name:  Kisspeptpin2
  • Gene name:  NA
  • Organism:  Lateolabrax japonicus
  • Family:  KISS1 family
  • Source:  animal
  • Expression:  brain and gonads
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  FNFNPFGLRF
  • Length:  10
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Play a dominant stimulatory role in the regulation of the gonadotropic axis at least in teleosts
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002276_AF2.pdbhor002276_ESM.pdb

Physical Information

Mass: 141914 Formula: C63H83N15O13
Absent amino acids: ACDEHIKMQSTVWY Common amino acids: F
pI: 10.55 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: 15 Boman Index: -1042
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 39
Instability Index: 2961 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  19084576
  • Title:  Evidence for Two Distinct KiSS Genes in Non-Placental Vertebrates That Encode Kisspeptins With Different Gonadotropin-Releasing Activities in Fish and Mammals