General Information

  • ID:  hor002274
  • Uniprot ID:  P21147
  • Protein name:  Leucokinin-8
  • Gene name:  OLE1
  • Organism:  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • Family:  Fatty acid desaturase type 1 family
  • Source:  Fungi
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Saccharomyces cerevisiae (species), Saccharomyces (genus), Saccharomycetaceae (family), Saccharomycetales (order), Saccharomycetes (class), Saccharomycotina (subphylum), saccharomyceta, Ascomycota (phylum), Dikarya (subkingdom), Fungi (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0004768 stearoyl-CoA 9-desaturase activity; GO:0005506 iron ion binding; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; GO:0020037 heme binding; GO:0046872 metal ion binding
  • GO BP:  GO:0000001 mitochondrion inheritance; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006636 unsaturated fatty acid biosynthetic process; GO:0022900 electron transport chain
  • GO CC:  GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane

Sequence Information

  • Sequence:  GADFYSWG
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates contractile activity of cockroach protodeum
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9QXV0-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q9QXV0-F1.pdbhor002274_AF2.pdbhor002274_ESM.pdb

Physical Information

Mass: 102697 Formula: C43H51N9O13
Absent amino acids: CEHIKLMNPQRTV Common amino acids: G
pI: 3.75 Basic residues: 0
Polar residues: 4 Hydrophobic residues: 3
Hydrophobicity: -33.75 Boman Index: -326
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 12.5
Instability Index: 588.75 Extinction Coefficient cystines: 6990
Absorbance 280nm: 998.57

Literature

  • PubMed ID:  NA
  • Title:  Isolation, primary structure and synthesis of leucokinins VII and VIII: the final members of this new family of cephalomyotropic peptides isolated from head extracts of Leucophaea maderae.