General Information

  • ID:  hor002271
  • Uniprot ID:  P19987
  • Protein name:  Leucokinin-5
  • Gene name:  NA
  • Organism:  Rhyparobia maderae (Madeira cockroach) (Leucophaea maderae)
  • Family:  NA
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rhyparobia (genus), Oxyhaloinae (subfamily), Blaberidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GSGFSSWG
  • Length:  8(1-8)
  • Propeptide:  GSGFSSWG
  • Signal peptide:  NA
  • Modification:  T8 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates contractile activity of cockroach protodeum
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P01189-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P01189-F1.pdbhor002271_AF2.pdbhor002271_ESM.pdb

Physical Information

Mass: 90882 Formula: C35H45N9O12
Absent amino acids: ACDEHIKLMNPQRTVY Common amino acids: GS
pI: 6.11 Basic residues: 0
Polar residues: 6 Hydrophobic residues: 2
Hydrophobicity: -21.25 Boman Index: -207
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 0
Instability Index: 1986.25 Extinction Coefficient cystines: 5500
Absorbance 280nm: 785.71

Literature

  • PubMed ID:  NA
  • Title:  Isolation, primary structure, and synthesis of leucokinins V and VI: myotropic peptides of Leucophaea maderae.