HORDB

ID: hor002246
Uniprot ID: O02036
Protein name: Kin-3
Gene name: NA
Organism: Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Family: Kinin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Stegomyia (subgenus), Aedes (genus), Aedini (tribe), Culicinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: NTGRVHRQPKVVIRNPFHAWG
Length: 21
Propeptide: MAMLLQVALPLLAAVSWGWELNENDDSLAKIIEGCEWTSRQNVISEILLDRYRKYAMYNFFLLDDVCAVHEWNKNLKEPEFSENNEAEDKSPTSAQNTQEHIPGNNFPPPAASNPPVNSSCAKSAKDFFICLSNQLGDPTLNAMLLDNLEVACDPRFSPVSAIQKRNSKYVSKQKFYSWGGKRNNPNVFYPWGGKRNTGRVHRQPKVVIRNPFHAWGGKRNQKDDNVF
Signal peptide: MAMLLQVALPLLAAVSWG
Modification: T21 Glycine amide
Glycosylation: NA
Mutagenesis: NA

Function: Stimulates both fluid secretion by the Malpighian tubules and hindgut contractions. Depolarize the transepithelial voltage of the Malpighian tubules in concentrations of less than 10(-9) M and increase the frequency of hindgut contractions at concentrations above 10(-8) M.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002246_AF2.pdb

hor002246_ESM.pdb

Mass:	282675	Formula:	C111H173N39O26
Absent amino acids:	CDELMSY	Common amino acids:	RV
pI:	12.81	Basic residues:	6
Polar residues:	5	Hydrophobic residues:	7
Hydrophobicity:	-86.67	Boman Index:	-5498
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	64.76
Instability Index:	2447.62	Extinction Coefficient cystines:	5500
Absorbance 280nm:	275