HORDB

ID: hor002206
Uniprot ID: Q90WW4
Protein name: Insulin-like growth factor II-A
Gene name: igf2-a
Organism: Xenopus laevis (African clawed frog)
Family: Insulin family
Source: Animal
Expression: Expressed both maternally and zygotically. Expressed in the dorsal midline during gastrulation and neurulation.
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005178 integrin binding; GO:0005179 hormone activity; GO:0008083 growth factor activity
GO BP: GO:0007165 signal transduction; GO:0007399 nervous system development; GO:0008284 positive regulation of cell population proliferation; GO:0030154 cell differentiation; GO:0060323 head morphogenesis
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: YRATETLCGGELVDTLQFVCGDRGFYFSTNNGRSNRRPNRGIVDVCCFKSCDLELLETYCAKPTKNE
Length: 67(57-123)
Propeptide: MEQLSCKHRSSSVEAEAQLCRQTESRSTQLPRMSVMRHLFLLSITFLVYTLDSAKAYRATETLCGGELVDTLQFVCGDRGFYFSTNNGRSNRRPNRGIVDVCCFKSCDLELLETYCAKPTKNERDVSTAPATAIPPLSKQDLYHKHHHTKSSKYDIWQRKSIHRLRRGVPAIVRARQYRLLMEKAEEAEQALSHRPLTTLPITRPLRLQQASEPSHN
Signal peptide: MEQLSCKHRSSSVEAEAQLCRQTESRSTQLPRMSVMRHLFLLSITFLVYTLDSAKA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002206_AF2.pdb

hor002206_ESM.pdb

Mass:	875393	Formula:	C324H508N94O104S6
Absent amino acids:	HMW	Common amino acids:	CGLRTEN
pI:	6.33	Basic residues:	9
Polar residues:	29	Hydrophobic residues:	17
Hydrophobicity:	-49.85	Boman Index:	-16042
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	61.04
Instability Index:	2446.72	Extinction Coefficient cystines:	4845
Absorbance 280nm:	73.41