General Information

  • ID:  hor002197
  • Uniprot ID:  P01348
  • Protein name:  Relaxin B chain
  • Gene name:  RLN
  • Organism:  Sus scrofa (Pig)
  • Family:  Insulin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0001556 oocyte maturation; GO:0001832 blastocyst growth; GO:0007165 signal transduction; GO:0030317 flagellated sperm motility; GO:0046326 positive regulation of glucose import; GO:0050679 positive regulation of epithelial cell proliferation; GO:2000344 positive regulation of acrosome reaction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QSTNDFIKACGRELVRLWVEICGSVSWGRTAL
  • Length:  32(25-56)
  • Propeptide:  MPRLFSYLLGVWLLLSQLPREIPGQSTNDFIKACGRELVRLWVEICGSVSWGRTALSLEEPQLETGPPAETMPSSITKDAEILKMMLEFVPNLPQELKATLSERQPSLRELQQSASKDSNLNFEEFKKIILNRQNEAEDKSLLELKNLGLDKHSRKKRLFRMTLSEKCCQVGCIRKDIARLC
  • Signal peptide:  MPRLFSYLLGVWLLLSQLPREIPG
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  RXFP1
  • Target Unid:  A0A5G2QC39
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P01348-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002197_AF2.pdbhor002197_ESM.pdb

Physical Information

Mass: 414927 Formula: C158H252N46O46S2
Absent amino acids: HMPY Common amino acids: GLRSV
pI: 8.23 Basic residues: 4
Polar residues: 11 Hydrophobic residues: 13
Hydrophobicity: 8.44 Boman Index: -4681
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 94.38
Instability Index: 3496.88 Extinction Coefficient cystines: 11125
Absorbance 280nm: 358.87

Literature

  • PubMed ID:  876374
  • Title:  Primary Structure of Porcine Relaxin: Homology With Insulin and Related Growth Factors.
  • PubMed ID:  851452
  • Title:   Primary Structure of the B-chain of Porcine Relaxin