HORDB

ID: hor002123
Uniprot ID: P22969
Protein name: Relaxin B chain
Gene name: RLN
Organism: Equus caballus (Horse)
Family: Insulin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Equus (genus), Equidae (family), Perissodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: QKPDDVIKACGRELARLRIEICGSLSWK
Length: 28(26-53)
Propeptide: MRRLFLSHVLGAWLLLSQLPRELSGQKPDDVIKACGRELARLRIEICGSLSWKKTVLRLEEPGLEAGQPVEIVSSSISKDAEALNTKLGLNSNLPKEQKATLSERQPSWRELLQQPALKDSNLNLEEFEETILKTQSEVEDDSLSELKNLGLDKHSRKKRMIQLSHKCCYWGCTRKELARQC
Signal peptide: MRRLFLSHVLGAWLLLSQLPRELSG
Modification: T1 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002123_AF2.pdb

hor002123_ESM.pdb

Mass:	366755	Formula:	C138H234N42O40S2
Absent amino acids:	FHMNTY	Common amino acids:	IKLR
pI:	8.81	Basic residues:	6
Polar residues:	6	Hydrophobic residues:	10
Hydrophobicity:	-35.36	Boman Index:	-6086
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	101.07
Instability Index:	4636.79	Extinction Coefficient cystines:	5625
Absorbance 280nm:	208.33