HORDB

ID: hor002066
Uniprot ID: P80090
Protein name: Molluscan insulin-related peptide III
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: Insulin family
Source: animal
Expression: Expressed in the cerebral light-green cells which are giant neuroendocrines cells involved in the control of growth.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle

Sequence: ESRPSIVCECCFNQCTVQELLAYC
Length: 24
Propeptide: MASVHLTLTKAFMVTVFLTLLLNVSITRGTTQHTCSILSRPHPRGLCGSTLANMVQWLCSTYTTSSKVKRQAEPDEEDDAMSKIMISKKRALSYLTKRESRPSIVCECCFNQCTVQELLAYC
Signal peptide: MASVHLTLTKAFMVTVFLTLLLNVSITRG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002066_AF2.pdb

hor002066_ESM.pdb

Mass:	314960	Formula:	C114H180N30O38S5
Absent amino acids:	DGHKMW	Common amino acids:	C
pI:	3.98	Basic residues:	1
Polar residues:	10	Hydrophobic residues:	7
Hydrophobicity:	28.75	Boman Index:	-2855
Half-Life:	1 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	77.08
Instability Index:	7177.92	Extinction Coefficient cystines:	1740
Absorbance 280nm:	75.65

PubMed ID: 1572366
Title: Isolation and chemical characterization of a novel insulin-related neuropeptide from the freshwater snail, Lymnaea stagnalis.