HORDB

ID: hor002063
Uniprot ID: P25289
Protein name: Molluscan insulin-related peptide 2 B chain
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: Insulin family
Source: Animal
Expression: Expressed in the cerebral light-green cells which are giant neuroendocrines cells involved in the control of growth.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle

Sequence: QSSCSLSSRPHPRGICGSNLAGFRAFICSNQNSPSMV
Length: 37(32-68)
Propeptide: MVGVRLVFTNAFVVTVLLTLLLDVVVKPAEGQSSCSLSSRPHPRGICGSNLAGFRAFICSNQNSPSMVKRDAETGWLLPETMVKRNAETDLDDPLRNIKLSSESALTYLTKRQRTTNLVCECCFNYCTPDVVRKYCY
Signal peptide: MVGVRLVFTNAFVVTVLLTLLLDVVVKPAEG
Modification: T1 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002063_AF2.pdb

hor002063_ESM.pdb

Mass:	453967	Formula:	C161H259N53O52S4
Absent amino acids:	DEKTWY	Common amino acids:	S
pI:	9	Basic residues:	4
Polar residues:	18	Hydrophobic residues:	9
Hydrophobicity:	-21.62	Boman Index:	-6871
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	55.41
Instability Index:	5863.24	Extinction Coefficient cystines:	125
Absorbance 280nm:	3.47

PubMed ID: 1350761
Title: Purification and Sequencing of Molluscan Insulin-Related Peptide II From the Neuroendocrine Light Green Cells in Lymnaea Stagnalis