HORDB

ID: hor002062
Uniprot ID: P07223
Protein name: Molluscan insulin-related peptide 1 A chain
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: Insulin family
Source: animal
Expression: Expressed in the cerebral light-green cells which are giant neuroendocrines cells involved in the control of growth.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle

Sequence: QGTTNIVCECCMKPCTLSELRQYCP
Length: 25
Propeptide: MAGVRLVFTKAFMVTVLLTLLLNIGVKPAEGQFSACNINDRPHRRGVCGSALADLVDFACSSSNQPAMVKRNAETDLDDPLRNIKLSSESALTYLTKRQGTTNIVCECCMKPCTLSELRQYCP
Signal peptide: MAGVRLVFTKAFMVTVLLTLLLNIGVKPAEG
Modification: T1 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002062_AF2.pdb

hor002062_ESM.pdb

Mass:	324960	Formula:	C115H190N32O38S6
Absent amino acids:	ADFHW	Common amino acids:	C
pI:	6.1	Basic residues:	2
Polar residues:	12	Hydrophobic residues:	4
Hydrophobicity:	-12	Boman Index:	-3457
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	58.4
Instability Index:	7979.6	Extinction Coefficient cystines:	1740
Absorbance 280nm:	72.5

PubMed ID: 1526314
Title: Purification and Sequencing of Molluscan Insulin-Related Peptide I (MIP I) From the Neuroendocrine Light Green Cells of Lymnaea Stagnalis