HORDB

ID: hor002060
Uniprot ID: P15131
Protein name: LIRP B chain
Gene name: NA
Organism: Locusta migratoria (Migratory locust)
Family: Insulin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: SGAPQPVARYCGEKLSNALKLVCRGNYNTMF
Length: 31
Propeptide: MWKLCLRLLAVLAVCLSTATQAQSDLFLLSPKRSGAPQPVARYCGEKLSNALKLVCRGNYNTMFKKASQDVSDSESEDNYWSGQSADEAAEAAAAALPPYPILARPSAGGLLTGAVFRRRTRGVFDECCRKSCSISELQTYCGRR
Signal peptide: MWKLCLRLLAVLAVCLSTA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002060_AF2.pdb

hor002060_ESM.pdb

Mass:	392421	Formula:	C147H235N43O43S3
Absent amino acids:	DHIW	Common amino acids:	AGLN
pI:	9.37	Basic residues:	4
Polar residues:	13	Hydrophobic residues:	9
Hydrophobicity:	-28.06	Boman Index:	-4388
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	66.13
Instability Index:	1049.35	Extinction Coefficient cystines:	3105
Absorbance 280nm:	103.5

PubMed ID: 1935945
Title: Isolation and structural characterization of an insulin-related molecule, a predominant neuropeptide from Locusta migratoria.