HORDB

ID: hor002034
Uniprot ID: Q95336
Protein name: Progonadoliberin-2
Gene name: GNRH2
Organism: Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri)
Family: GnRH family
Source: Animal
Expression: Midbrain.
Disease: NA
Comments: NA
Taxonomy: Tupaia (genus), Tupaiidae (family), Scandentia (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: QHWSHGWYPGGKRASNSPQDPQSALRPPAPSAAQTAHSFRSAALASPEDSVPWEGRTTAGWSLRRKQHLMRTLLSAAGAPRPAAVPIKP
Length: 89(26-114)
Propeptide: MASSMLGFLLLLLLLMAAHPGPSEAQHWSHGWYPGGKRASNSPQDPQSALRPPAPSAAQTAHSFRSAALASPEDSVPWEGRTTAGWSLRRKQHLMRTLLSAAGAPRPAAVPIKP
Signal peptide: MASSMLGFLLLLLLLMAAHPGPSEA
Modification: T10 Glycine amide
Glycosylation: NA
Mutagenesis: NA

Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002034_AF2.pdb

hor002034_ESM.pdb

Mass:	1112652	Formula:	C422H654N134O120S
Absent amino acids:	C	Common amino acids:	A
pI:	12.07	Basic residues:	15
Polar residues:	23	Hydrophobic residues:	29
Hydrophobicity:	-74.38	Boman Index:	-17791
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	54.04
Instability Index:	7841.24	Extinction Coefficient cystines:	23490
Absorbance 280nm:	266.93