HORDB

ID: hor002027
Uniprot ID: O97686
Protein name: GnRH-associated peptide 2
Gene name: GNRH2
Organism: Suncus murinus (Asian house shrew) (Musk shrew)
Family: GnRH family
Source: Animal
Expression: Midbrain.
Disease: NA
Comments: NA
Taxonomy: Suncus (genus), Crocidurinae (subfamily), Soricidae (family), Eulipotyphla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: SPDSPQDPQPAPRFPEGYWLGLAAGNPRQSTQSLPSKALAPPEDTVSEEAKTMAWWHLQKQRLIQTLLPRP
Length: 71(40-110)
Propeptide: MASIGQGLVLLLLLLLLTAQPGPLKAQHWSHGWYPGGKRSPDSPQDPQPAPRFPEGYWLGLAAGNPRQSTQSLPSKALAPPEDTVSEEAKTMAWWHLQKQRLIQTLLPRP
Signal peptide: MASIGQGLVLLLLLLLLTAQPGPLKA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002027_AF2.pdb

hor002027_ESM.pdb

Mass:	916467	Formula:	C355H549N99O105S
Absent amino acids:	C	Common amino acids:	P
pI:	7.55	Basic residues:	8
Polar residues:	15	Hydrophobic residues:	21
Hydrophobicity:	-85.92	Boman Index:	-13450
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	63.38
Instability Index:	9327.04	Extinction Coefficient cystines:	17990
Absorbance 280nm:	257