HORDB

ID: hor002025
Uniprot ID: O97686
Protein name: Progonadoliberin-2
Gene name: GNRH2
Organism: Suncus murinus (Asian house shrew) (Musk shrew)
Family: GnRH family
Source: Animal
Expression: Midbrain.
Disease: NA
Comments: NA
Taxonomy: Suncus (genus), Crocidurinae (subfamily), Soricidae (family), Eulipotyphla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: QHWSHGWYPGGKRSPDSPQDPQPAPRFPEGYWLGLAAGNPRQSTQSLPSKALAPPEDTVSEEAKTMAWWHLQKQRLIQTLLPRP
Length: 84(27-110)
Propeptide: MASIGQGLVLLLLLLLLTAQPGPLKAQHWSHGWYPGGKRSPDSPQDPQPAPRFPEGYWLGLAAGNPRQSTQSLPSKALAPPEDTVSEEAKTMAWWHLQKQRLIQTLLPRP
Signal peptide: MASIGQGLVLLLLLLLLTAQPGPLKA
Modification: T10 Glycine amide
Glycosylation: NA
Mutagenesis: NA

Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002025_AF2.pdb

hor002025_ESM.pdb

Mass:	1097427	Formula:	C429H645N123O121S
Absent amino acids:	C	Common amino acids:	P
pI:	9.81	Basic residues:	12
Polar residues:	20	Hydrophobic residues:	23
Hydrophobicity:	-102.38	Boman Index:	-16589
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	53.57
Instability Index:	9131.43	Extinction Coefficient cystines:	30480
Absorbance 280nm:	367.23