General Information

  • ID:  hor001997
  • Uniprot ID:  NA
  • Protein name:  GnRH II
  • Gene name:  NA
  • Organism:  marmoset
  • Family:  GnRH family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  EHSHGWYPG
  • Length:  9
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T10 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Gonadotrope functioning
  • Mechanism:  Couples to G(alpha)q/11 and also activates extracellular signal-regulated kinase (ERK1/2)
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: Ligand binding:0.45+/-0.05nmol
  • EC50: InsP production:0.45+/-0.05nmal
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001997_AF2.pdbhor001997_ESM.pdb

Physical Information

Mass: 121197 Formula: C49H60N14O14
Absent amino acids: ACDFIKLMNQRTV Common amino acids: GH
pI: 6.5 Basic residues: 2
Polar residues: 4 Hydrophobic residues: 1
Hydrophobicity: -170 Boman Index: -1546
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 1641.11 Extinction Coefficient cystines: 6990
Absorbance 280nm: 873.75

Literature

  • PubMed ID:  11493674
  • Title:  A Novel Mammalian Receptor for the Evolutionarily Conserved Type II GnRH