HORDB

ID: hor001954
Uniprot ID: O42144
Protein name: Glucagon-like peptide 1B
Gene name: gcg2
Organism: Xenopus laevis (African clawed frog)
Family: Glucagon family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Sequence: HAEGTYTNDVTEYLEEKATKAFIEWLIKGKP
Length: 31(142-172)
Propeptide: MKSTCYMIGILLLILQNTYQSPVPEADGSSRSVKAARNEAVDDSEQLKEVKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRSGGLSRRNADYERHAEGTFTSDVTQHLDEKAAKEFIDWLINGGPTKEIISRRNAEIERHAEGTYTNDVTEYLEEKATKAFIEWLIKGKPKKIRYSRHAEGTFTNDMTNYLEEKAAKEFVGWLINGRPKRKDLLEEH
Signal peptide: MKSTCYMIGILLLILQNTYQ
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001954_AF2.pdb

hor001954_ESM.pdb

Mass:	411830	Formula:	C164H249N39O51
Absent amino acids:	CMQRS	Common amino acids:	E
pI:	4.79	Basic residues:	5
Polar residues:	9	Hydrophobic residues:	10
Hydrophobicity:	-74.19	Boman Index:	-5049
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	69.35
Instability Index:	1600	Extinction Coefficient cystines:	8480
Absorbance 280nm:	282.67