HORDB

ID: hor001952
Uniprot ID: O42143
Protein name: Glucagon-like peptide 2
Gene name: gcg1
Organism: Xenopus laevis (African clawed frog)
Family: Glucagon family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Sequence: HADGSFTNDINKVLDIIAAQEFLDWVINTQETE
Length: 33(227-259)
Propeptide: MKSTCYMIGILLMILQNTYQSPVPETDANSRSVKAARNEAVDDSEQLKEVKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRSGELSRRNADYERHAEGTFTSDVTQQLDEKAAKEFIDWLINGGPSKEIISRRNAEFERHAEGTYTNDVTEYLEEKAAKEFIEWLIKGKPKKIRYSRHAEGTFTNDMTNYLEEKAAKEFVGWLIKGRPKRNFSEVHSVEEMDRRHADGSFTNDINKVLDIIAAQEFLDWVINT
Signal peptide: MKSTCYMIGILLMILQNTYQ
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001952_AF2.pdb

hor001952_ESM.pdb

Mass:	431907	Formula:	C166H252N42O57
Absent amino acids:	CMPRY	Common amino acids:	DI
pI:	3.71	Basic residues:	2
Polar residues:	8	Hydrophobic residues:	14
Hydrophobicity:	-25.15	Boman Index:	-5537
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	97.58
Instability Index:	1725.15	Extinction Coefficient cystines:	5500
Absorbance 280nm:	171.88