General Information

  • ID:  hor001920
  • Uniprot ID:  P41585
  • Protein name:  Pituitary adenylate cyclase-activating polypeptide
  • Gene name:  NA
  • Organism:  Oncorhynchus nerka (Sockeye salmon) (Salmo nerka)
  • Family:  Glucagon family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYRQRYRNK
  • Length:  38(129-166)
  • Propeptide:  MSSKATLALLIYGIIMHYSVYSSPLGLNYPNLRLENEVYDEDGNSLPALAFDSDQIAIRSPPSVADDLYTLYYPPEKGTERHADGMFNKAYRKALGQLSARKYLHSLMAKRVGGGSTMEDDTEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYRQRYRNKGRRLGYL
  • Signal peptide:  MSSKATLALLIYGIIMHYSVYS
  • Modification:  T38 Lysine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Play pivotal roles as a neurotransmitter and/or a neuromodulator
  • Mechanism:  [Isoform Short]: Lacks the GHRH-like sequence.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P41585-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001920_AF2.pdbhor001920_ESM.pdb

Physical Information

Mass: 531549 Formula: C207H330N66O55S
Absent amino acids: CEPW Common amino acids: R
pI: 11.07 Basic residues: 12
Polar residues: 12 Hydrophobic residues: 9
Hydrophobicity: -123.68 Boman Index: -13508
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 53.95
Instability Index: 2795 Extinction Coefficient cystines: 7450
Absorbance 280nm: 201.35

Literature

  • PubMed ID:  NA
  • Title:  NA