HORDB

ID: hor001868
Uniprot ID: P09910
Protein name: Secretin
Gene name: SCT
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Family: Glucagon family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Canis lupus (species), Canis (genus), Canidae (family), Caniformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0046659 digestive hormone activity
GO BP: GO:0002024 diet induced thermogenesis; GO:0007165 signal transduction; GO:0021766 hippocampus development; GO:0031667 response to nutrient levels; GO:0032098 regulation of appetite; GO:0048167 regulation of synaptic plasticity; GO:0050996 positive regulation of lipid catabolic process
GO CC: GO:0005576 extracellular region

Function: Adjust the pH of the duodenum
Mechanism: inhibiting the secretion of gastric acid from the parietal cells of the stomach and stimulating the production of bicarbonate (NaHCO3) from the ductal cells of the pancreas
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P09910-F1.pdb

hor001868_AF2.pdb

hor001868_ESM.pdb

Mass:	353439	Formula:	C131H221N43O42
Absent amino acids:	CIKMNPWY	Common amino acids:	L
pI:	10.25	Basic residues:	5
Polar residues:	8	Hydrophobic residues:	9
Hydrophobicity:	-46.3	Boman Index:	-7627
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	101.11
Instability Index:	6373.7	Extinction Coefficient cystines:	0
Absorbance 280nm:	0