HORDB

ID: hor001855
Uniprot ID: P81264
Protein name: Prolactin-releasing peptide PrRP31
Gene name: PRLH
Organism: Bos taurus (Bovine)
Family: FMRFamide related peptide family
Source: Animal
Expression: Medulla oblongata and hypothalamus.
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0031861 prolactin-releasing peptide receptor binding
GO BP: GO:0007186 G protein-coupled receptor signaling pathway; GO:0007631 feeding behavior; GO:0043434 response to peptide hormone
GO CC: GO:0005576 extracellular region

Sequence: SRAHQHSMEIRTPDINPAWYAGRGIRPVGRF
Length: 31(23-53)
Propeptide: MKAVGAWLLCLLLLGLALQGAASRAHQHSMEIRTPDINPAWYAGRGIRPVGRFGRRRAAPGDGPRPGPRRVPACFRLEGGAEPSRALPGRLTAQLVQE
Signal peptide: MKAVGAWLLCLLLLGLALQGAA
Modification: T31 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Stimulates prolactin (PRL) release and regulates the expression of prolactin
Mechanism: NA
Cross BBB: NA
Target: PRLHR
Target Unid: Q4EW11
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q9BZL1-F1.pdb

hor001855_AF2.pdb

hor001855_ESM.pdb

Mass:	411232	Formula:	C157H243N53O42S
Absent amino acids:	CKL	Common amino acids:	R
pI:	11.91	Basic residues:	7
Polar residues:	8	Hydrophobic residues:	9
Hydrophobicity:	-82.58	Boman Index:	-8643
Half-Life / Aliphatic Index:	1.9 hour	Aliphatic Index:	56.77
Instability Index:	3406.45	Extinction Coefficient cystines:	6990
Absorbance 280nm:	233