HORDB

ID: hor001828
Uniprot ID: A0A8B6XQB0
Protein name: Hydra-RFamide I
Gene name: LOC100192288
Organism: Hydra vulgaris (Hydra) (Hydra attenuata)
Family: FMRFamide related peptide family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Hydra (genus), Hydridae (family), Aplanulata (suborder), Anthoathecata (order), Hydroidolina (subclass), Hydrozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: NA

Sequence: QWLGGRFG
Length: 8(373-380)
Propeptide: MATNMALLTFILFATSIFMLAKADSQNEDNQKYAGIARSLKVLLQNYYQKQEEKSDIQNIIEKFSEYQNTDHKRNDKTNPMIEKKDSDTENRFNREAIEQWFSGRFGLPNQKRNNEVNPMIEKKDSDIENRFNRESLEQWLSGRFGLTNQKRHNEANPMIEKKDSDTENRFNKETIEQWLSGRFGLTNHKRNNEVNPMIEKKDSDTENRFNRESLEQWLSGRFGLTNHKRNNEVNPMIEKKDSDTENRFNRESLE
Signal peptide: MATNMALLTFILFATSIFMLAKA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001828_AF2.pdb

hor001828_ESM.pdb

Mass:	104508	Formula:	C43H61N13O10
Absent amino acids:	ACDEHIKMNPSTVY	Common amino acids:	G
pI:	10.55	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	3
Hydrophobicity:	-43.75	Boman Index:	-741
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.75
Instability Index:	3960	Extinction Coefficient cystines:	5500
Absorbance 280nm:	785.71

PubMed ID: 9601069
Title: Three Different Prohormones Yield a Variety of Hydra-RFamide (Arg-Phe-NH2) Neuropeptides in Hydra Magnipapillata