HORDB

ID: hor001687
Uniprot ID: P19802
Protein name: QFYRI-amide
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: FARP (FMRFamide related peptide) family
Source: Animal
Expression: Expressed in 280 cells of the CNS including the EGP heart excitatory motoneurons.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: QFYRI
Length: 5(59-63)
Propeptide: MKTWSHVALLACLSIKWLTCVMADSIYCDDPDMCSMTKRFLRFGRALDTTDPFIRLRRQFYRIGRGGYQPYQDKRFLRFGRSEQPDVDDYLRDVVLQSEEPLYRKRRSTEAGGQSEEMTHRTARSAPEPAAENREIMKRETGAEDLDEEKRFMRFGRGDEEAEKRFMRFGKSFMRFGRDMSDVDKRFMRFGKRFMRFGREPGTDKRFMRFGREPGADKRFMRFGKSFDGEEENDDDLYYNESDADSNDDVDKRFM
Signal peptide: MKTWSHVALLACLSIKWLTCVMADSIYCDDPDMCS
Modification: T5 Isoleucine amide
Glycosylation: NA
Mutagenesis: NA

Function: Induces contractions in visceral and somatic musculature as well as in the heart. May play a role as cotransmitters or modulators in a number of significant neuronal systems
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q15726-F1.pdb

hor001687_AF2.pdb

hor001687_ESM.pdb

Mass:	79737	Formula:	C35H51N9O8
Absent amino acids:	ACDEGHKLMNPSTVW	Common amino acids:	FIQRY
pI:	9.35	Basic residues:	1
Polar residues:	1	Hydrophobic residues:	2
Hydrophobicity:	-40	Boman Index:	-1270
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	78
Instability Index:	2430	Extinction Coefficient cystines:	1490
Absorbance 280nm:	372.5