General Information

  • ID:  hor001658
  • Uniprot ID:  P84306
  • Protein name:  SchistoFLRFamide
  • Gene name:  NA
  • Organism:  Locusta migratoria (Migratory locust)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  Found in axons of the male accessory glands, the salivary glands, the heart, and the oviduct.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  PDVDHVFLRF
  • Length:  10(1-10)
  • Propeptide:  PDVDHVFLRF
  • Signal peptide:  NA
  • Modification:  T10 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Muscle inhibiting agent. Involved in the neural control of the visceral muscles of the heart, accessory glands and oviduct. May be involved in the regulation of saliva secretion.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001658_AF2.pdbhor001658_ESM.pdb

Physical Information

Mass: 140513 Formula: C59H85N15O15
Absent amino acids: ACEGIKMNQSTWY Common amino acids: DFV
pI: 5.41 Basic residues: 2
Polar residues: 0 Hydrophobic residues: 5
Hydrophobicity: 15 Boman Index: -1806
Half-Life: >20 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: ? Aliphatic Index 97
Instability Index: 569 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  7687352
  • Title:  Isolation, Identification, and Synthesis of PDVDHFLRFamide (SchistoFLRFamide) in Locusta Migratoria and Its Association With the Male Accessory Glands, the Salivary Glands, the Heart, and the Oviduct