HORDB

ID: hor001645
Uniprot ID: Q8JIM3
Protein name: fGRP-related peptide 2
Gene name: NA
Organism: Lithobates catesbeianus (American bullfrog) (Rana catesbeiana)
Family: FARP (FMRFamide related peptide) family
Source: Animal
Expression: Observed in the suprachiasmatic nucleus and in several telencephalic and diencephalic regions.
Disease: NA
Comments: NA
Taxonomy: Lithobates (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003674 molecular_function
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0046879 hormone secretion
GO CC: GO:0005576 extracellular region

Sequence: YLSGKTKVQSMANLPQRF
Length: 18(139-156)
Propeptide: MHLKIGTLTIRTIMLFTLCTFLTLFAFSTCFDETKTINLESQEIYDDLFESKEDLQNERNGNSDEYRYMGSNSINDINRYNRLSMQPENEFLQERSLKPAANLPLRFGRTSDDKIAKSIPSFDKIAKSIPNLPQRFGRYLSGKTKVQSMANLPQRFGRAQYTNHFVHSLDTLPLRFGRTPHSDRLQYEMNSHPLELKNPEEDSDRKKRQAMTFRIRTDLQM
Signal peptide: MHLKIGTLTIRTIMLFTLCTFLTLF
Modification: T18 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Primary role is to release GH from the pituitary. May act as an endogenous ligand in the bullfrog hypothalamo-hypophysial system.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001645_AF2.pdb

hor001645_ESM.pdb

Mass:	237182	Formula:	C92H150N26O26S
Absent amino acids:	CDEHIW	Common amino acids:	KLQS
pI:	10.9	Basic residues:	3
Polar residues:	6	Hydrophobic residues:	5
Hydrophobicity:	-56.11	Boman Index:	-3129
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	65
Instability Index:	5267.78	Extinction Coefficient cystines:	1490
Absorbance 280nm:	87.65