General Information

  • ID:  hor001635
  • Uniprot ID:  B0U7C5
  • Protein name:  Extended FMRFamide-10
  • Gene name:  NA
  • Organism:  Karoophasma botterkloofense (Gladiator) (Heel-walker)
  • Family:  FARP (FMRF amide related peptide) family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Karoophasma (genus), Austrophasmatidae (family), Mantophasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  PAPESSFIRDP
  • Length:  11(1-11)
  • Propeptide:  PAPESSFIRDP
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  FMRFamides and FMRFamide-like peptides are neuropeptides.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P01323-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P01323-F1.pdbhor001635_AF2.pdbhor001635_ESM.pdb

Physical Information

Mass: 139386 Formula: C54H82N14O18
Absent amino acids: CGHKLMNQTVWY Common amino acids: P
pI: 4.18 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -80 Boman Index: -2754
Half-Life: >20 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: ? Aliphatic Index 44.55
Instability Index: 9492.73 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  22508719
  • Title:  Peptidomics-based phylogeny and biogeography of Mantophasmatodea (Hexapoda).