HORDB

ID: hor001593
Uniprot ID: P41870
Protein name: QFYRF-amide
Gene name: NA
Organism: Cornu aspersum (Brown garden snail) (Helix aspersa)
Family: FARP (FMRFamide related peptide) family
Source: Animal
Expression: Central nervous system.
Disease: NA
Comments: NA
Taxonomy: Cornu (subgenus), Cornu (genus), Helicidae (family), Helicoidea (superfamily), Helicina, Stylommatophora (order), Eupulmonata (superorder), Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: QFYRF
Length: 5(47-51)
Propeptide: MTSLCLTIAPAVLSLICLSSYGWAEDNNGIHTLDDGDNDPFFRHNRQFYRFGRAFVPLWDNADDSLVRKNLLTHWSEFPLSPALSSSDVFSRNSRQFYRFGRSYPPYQDKRFLRFGRSHQPDIDEYLQALNSDQALYRKRRSEDGDSKEDGLNRVARSADANQQSKNTQSNKFGKDLQKRETKKEKLNANDDLEILSNEDDLEKKFMRFGKRFMRFGRGDEDESYDKRFMRFGKSLRHDQEFEKRFMRFGKRFMR
Signal peptide: MTSLCLTIAPAVLSLICLS
Modification: T5 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Can function as both cardioregulatory hormones and transmitters and may regulate cardiovascular function.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001593_AF2.pdb

hor001593_ESM.pdb

Mass:	83138	Formula:	C38H49N9O8
Absent amino acids:	ACDEGHIKLMNPSTVW	Common amino acids:	F
pI:	9.35	Basic residues:	1
Polar residues:	1	Hydrophobic residues:	2
Hydrophobicity:	-74	Boman Index:	-1464
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	0
Instability Index:	2430	Extinction Coefficient cystines:	1490
Absorbance 280nm:	372.5