General Information

  • ID:  hor001558
  • Uniprot ID:  B3EWK3
  • Protein name:  FMRFamide-like neuropeptide TPGQDFMRF-amide
  • Gene name:  NA
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  Detected in larvae and adults. |In larvae, expressed in the CNS and thoracic perisymapthetic organs (tPSO) but not in the ring gland or abdominal perisymapthetic organs (aPSO) (at protein level). In adults, expressed in brain and thoracic-abdominal gangli
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  TPGQDFMRF
  • Length:  9(1-9)
  • Propeptide:  TPGQDFMRF
  • Signal peptide:  NA
  • Modification:  T9 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  FMRFamides and FMRFamide-like peptides are neuropeptides.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001558_AF2.pdbhor001558_ESM.pdb

Physical Information

Mass: 124111 Formula: C49H71N13O14S
Absent amino acids: ACEHIKLNSVWY Common amino acids: F
pI: 6.34 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -74.44 Boman Index: -2250
Half-Life / Aliphatic Index: 7.2 hour Aliphatic Index: 0
Instability Index: 1353.33 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  20869420
  • Title:  Neuropeptides associated with the central nervous system of the cabbage root fly, Delia radicum (L).
  • PubMed ID:  22848525
  • Title:   Peptidomics of the agriculturally damaging larval stage of the cabbage root fly Delia radicum (Diptera: Anthomyiidae).