General Information

  • ID:  hor001530
  • Uniprot ID:  Q18184
  • Protein name:  EASAFGDIIGELKGKGLGGRMRF-amide
  • Gene name:  flp-27
  • Organism:  Caenorhabditis elegans
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  Each flp gene is expressed in a distinct set of neurons.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  EASAFGDIIGELKGKGLGGRMRF
  • Length:  23(38-60)
  • Propeptide:  MFSLTQILTFLLVAITLMTFSSAQPIDEERPIFMERREASAFGDIIGELKGKGLGGRMRFGKRSSSPDISLAEMRAIYGGDQSNIFNFK
  • Signal peptide:  MFSLTQILTFLLVAITLMTFSSA
  • Modification:  T23 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  FMRFamides and FMRFamide-like peptides are neuropeptides.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q18184-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001530_AF2.pdbhor001530_ESM.pdb

Physical Information

Mass: 280239 Formula: C106H173N31O31S
Absent amino acids: CHNPQTVWY Common amino acids: G
pI: 9.53 Basic residues: 4
Polar residues: 7 Hydrophobic residues: 8
Hydrophobicity: -12.17 Boman Index: -2943
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 76.52
Instability Index: -639.13 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  19456328
  • Title:  Identification of new members of the (short) neuropeptide F family in locusts and Caenorhabditis elegans.