General Information

  • ID:  hor001483
  • Uniprot ID:  Q1MX22
  • Protein name:  DPSFIRF-amide
  • Gene name:  RFa
  • Organism:  Bombyx mori (Silk moth)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  Expression is continuous throughout the developmental period, but is highest during the feeding period in the early half of the fifth instar stage (days 0-4). Expression decreases remarkably on day 5 before larvae start wandering on day 6, but stabilizes
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Bombyx (genus), Bombycinae (subfamily), Bombycidae (family), Bombycoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DPSFIRF
  • Length:  7(105-111)
  • Propeptide:  MNHPRSIAMLAALWLVVSVTSTPVRRSPDLEARRRSAIDRSMIRFGRSTLPVVPPAQPSFLQRYSAPQPAALTADDLMTFLRAYEEDYSSPVSKKSASFVRFGRDPSFIRFGRSVDEENSGYQAETNTYPQRRHRARNHFIRLGRDNELSESNDEDRYEVESERTKRSVVDPCNDCA
  • Signal peptide:  MNHPRSIAMLAALWLVVSVTS
  • Modification:  T7 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Regulates ecdysteroidogenesis
  • Mechanism:  Direct innervation of the prothoracic gland by reduce cAMP production via the receptor for myosuppressin.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q1MX22-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001483_AF2.pdbhor001483_ESM.pdb

Physical Information

Mass: 98819 Formula: C42H60N10O11
Absent amino acids: ACEGHKLMNQTVWY Common amino acids: F
pI: 6.34 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: -4.29 Boman Index: -1616
Half-Life / Aliphatic Index: 1.1 hour Aliphatic Index: 55.71
Instability Index: 3608.57 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  16707581
  • Title:  Regulation of insect steroid hormone biosynthesis by innervating peptidergic neurons.