General Information

  • ID:  hor001455
  • Uniprot ID:  P43173
  • Protein name:  Neuropeptide AF11
  • Gene name:  NA
  • Organism:  Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Ascaris (genus), Ascarididae (family), Ascaridoidea (superfamily), Ascaridomorpha (infraorder), Spirurina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SDIGISEPNFLRF
  • Length:  13(1-13)
  • Propeptide:  SDIGISEPNFLRF
  • Signal peptide:  NA
  • Modification:  T13 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001455_AF2.pdbhor001455_ESM.pdb

Physical Information

Mass: 170888 Formula: C68H103N17O21
Absent amino acids: ACHKMQTVWY Common amino acids: FIS
pI: 4.18 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 5
Hydrophobicity: -1.54 Boman Index: -2223
Half-Life / Aliphatic Index: 1.9 hour Aliphatic Index: 90
Instability Index: 3558.46 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  7651904
  • Title:  Eight novel FMRFamide-like neuropeptides isolated from the nematode Ascaris suum.