HORDB

ID: hor001395
Uniprot ID: Q5U900
Protein name: FRF2
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: FMRFamide related peptide family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: NA

Sequence: QGSLFRF
Length: 7(90-96)
Propeptide: MEHISLAMVLAFLTALICTAHSDDGAHSSSVKAFESSNHESHQPQKRSPSASPSAYDEDLLLADSGLMDAPYNLDDVDKRNTLFRFGKRQGSLFRFGKRGGSLFRFGKRGTLLRFGKRGGSLFRFGRSGPSDSSDSENMEDKRTLFRFGKRSDLDLLRDALAEAEYSNLPVYAENEPMKRDIQGFHWGMDNDEQ
Signal peptide: MEHISLAMVLAFLTALICTAHS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: inhibit LGCs and CDCs to suppress host metabolism and reproduction.
Mechanism: Activate the K + current in cells
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: 3.1*10(-7)m
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001395_AF2.pdb

hor001395_ESM.pdb

Mass:	96117	Formula:	C40H59N11O10
Absent amino acids:	ACDEHIKMNPTVWY	Common amino acids:	F
pI:	10.55	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	3
Hydrophobicity:	2.86	Boman Index:	-1204
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	55.71
Instability Index:	857.14	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 15715658
Title: LFRFamides: A Novel Family of Parasitation-Induced -RFamide Neuropeptides That Inhibit the Activity of Neuroendocrine Cells in Lymnaea Stagnalis