General Information

  • ID:  hor001158
  • Uniprot ID:  D9I8P2
  • Protein name:  PepGE
  • Gene name:  AFP-13
  • Organism:  Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Ascaris (genus), Ascarididae (family), Ascaridoidea (superfamily), Ascaridomorpha (infraorder), Spirurina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GNSYRSFFNPNEYTVVE
  • Length:  17(40-56)
  • Propeptide:  MAINSISCLITMLAITVAVSTLESSEIRMLESEFLDGKRGNSYRSFFNPNEYTVVERRDSKLMDPLIRFGKRTNIMGENRLNRNLRAEGLSSPLIRFGKRTPPEEDLLGRFTRDPQQRIVTDETVLRFGRSSAPAAA
  • Signal peptide:  MAINSISCLITMLAITVAVSTLES
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-D9I8P2-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001158_AF2.pdbhor001158_ESM.pdb

Physical Information

Mass: 230868 Formula: C91H127N23O30
Absent amino acids: ACDHIKLMQW Common amino acids: N
pI: 4.26 Basic residues: 1
Polar residues: 9 Hydrophobic residues: 4
Hydrophobicity: -87.65 Boman Index: -4313
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 34.12
Instability Index: 1310 Extinction Coefficient cystines: 2980
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  20806053
  • Title:  Mapping Neuropeptide Expression by Mass Spectrometry in Single Dissected Identified Neurons From the Dorsal Ganglion of the Nematode Ascaris Suum