General Information

  • ID:  hor001105
  • Uniprot ID:  NA
  • Protein name:  EPYLRFamide
  • Gene name:  NA
  • Organism:  NA
  • Family:  FMRFamide related peptide family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  EPYLRF
  • Length:  6
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Decrease ACh-current through elevation of the basal intracellular level of the putative endogenous agonist of IP(3)Rs which activates release of Ca(2+) from intracellular stores.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001105_AF2.pdbhor001105_ESM.pdb

Physical Information

Mass: 91330 Formula: C40H57N9O10
Absent amino acids: ACDGHIKMNQSTVW Common amino acids: EFLPRY
pI: 6.4 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -71.67 Boman Index: -1397
Half-Life / Aliphatic Index: 1 hour Aliphatic Index: 65
Instability Index: 7253.33 Extinction Coefficient cystines: 1490
Absorbance 280nm: 298

Literature

  • PubMed ID:  12609746
  • Title:  EPYLRFamide-mediated Reduction of Acetylcholine-Induced Inward Currents in Helix Lucorum-Identified Neurones: Role of NAADP-dependent and IP3-dependent Ca2+ Release From Internal Stores, Calmodulin and Ca2+/calmodulin-dependent Protein Kinase II