HORDB

ID: hor001100
Uniprot ID: A0A914KQ46
Protein name: APLDRSALVRFamide
Gene name: Mi-flp-7
Organism: Meloidogyne incognita (Southern root-knot nematode)
Family: FMRFamide related peptide family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Meloidogyne incognita group, Meloidogyne (genus), Meloidogyninae (subfamily), Meloidogynidae (family), Tylenchoidea (superfamily), Tylenchomorpha (infraorder), Tylenchina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: APLDRSALVRF
Length: 11(69-79)
Propeptide: MAQIIFNTLLATLIFSAFFISRFSNGQLTNDFGSQLMSLQDFGDDYNNAIFADIDGDNENSYESMAKRAPLDRSALVRFGKRAPLDRSALVRFGKRAPLDRAAMVRFGKRAPLDRAAMVRFGKRAPFDRSSMVRFGKRK
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Exert potent physiological effects on locomotory, feeding and reproductive musculature and also act as neuromodulators.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001100_AF2.pdb

hor001100_ESM.pdb

Mass:	142301	Formula:	C56H93N17O15
Absent amino acids:	CEGHIKMNQTWY	Common amino acids:	ALR
pI:	10.4	Basic residues:	2
Polar residues:	1	Hydrophobic residues:	6
Hydrophobicity:	30	Boman Index:	-2148
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	115.45
Instability Index:	5969.09	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 19843350
Title: FMRFamide-like peptides in root knot nematodes and their potential role in nematode physiology.