General Information

  • ID:  hor001096
  • Uniprot ID:  A0A1C8Y949
  • Protein name:  SIFamide
  • Gene name:  NA
  • Organism:  Macrobrachium rosenbergii (Giant fresh water prawn)
  • Family:  FMRFamide related peptide family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Macrobrachium (genus), Palaemonidae (family), Palaemonoidea (superfamily), Caridea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GYRKPPFNGSIF
  • Length:  12(28-39)
  • Propeptide:  MSVQTRLVVAVMVVLVVLAVFTDHASAGYRKPPFNGSIFGKRSGGDPAYESGKTLASICQVAVEACSAWFPGPEKK
  • Signal peptide:  MSVQTRLVVAVMVVLVVLAVFTDHASA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Intermediate periventricular nucleus (IPe) in the hypothalamus
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A1C8Y949-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001096_AF2.pdbhor001096_ESM.pdb

Physical Information

Mass: 157895 Formula: C66H95N17O16
Absent amino acids: ACDEHLMQTVW Common amino acids: FGP
pI: 10.45 Basic residues: 2
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -65.83 Boman Index: -1789
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 32.5
Instability Index: 129.17 Extinction Coefficient cystines: 1490
Absorbance 280nm: 135.45

Literature

  • PubMed ID:  20040755
  • Title:  GYRKPPFNGSIFamide (Gly-SIFamide) Modulates Aggression in the Freshwater Prawn Macrobrachium Rosenbergii