General Information

  • ID:  hor001095
  • Uniprot ID:  B5ABV2
  • Protein name:  Gonadotropin-inhibitory hormone
  • Gene name:  NA
  • Organism:  Macaca mulatta (Rhesus macaque)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  intermediate periventricular nucleus (IPe) in the hypothalamus
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Macaca (genus), Cercopithecinae (subfamily), Cercopithecidae (family), Cercopithecoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SGRNMEVSLVRQVLNLPQRF
  • Length:  20(112-131)
  • Propeptide:  MEIISSKLFILLTLATSSLLTSNISCADELMMSSLHNKENYDKYSEPRGYPKRERSLNFEELKDWGPKNVIKMSTPAVNKMPHSVTNLPLRFGRTTEEERSTGAIANLPLRSGRNMEVSLVRQVLNLPQRFGRTTTAKSVCRTLSDLCQGSLHSPCANDLFYSMTCQHQEIQNPDQKRSRRLVFQKMDDAELKQEK
  • Signal peptide:  MEIISSKLFILLTLATSSLLTSNISC
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Modulates the reproductive physiology of birds and mammals by inhibiting gonadotropin secretion from the anterior pituitary gland;inhibit reproductive behaviors, possibly via action within the brain
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-B5ABV2-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001095_AF2.pdbhor001095_ESM.pdb

Physical Information

Mass: 268280 Formula: C101H171N33O29S
Absent amino acids: ACDHIKTWY Common amino acids: LRV
pI: 12.2 Basic residues: 3
Polar residues: 5 Hydrophobic residues: 7
Hydrophobicity: -29.5 Boman Index: -4958
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 102
Instability Index: 4079 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  19844991
  • Title:  Gonadotropin-inhibitory Hormone Identification, cDNA Cloning, and Distribution in Rhesus Macaque Brain